The caption of this 1870 lithographic print reads as follows:
FROM NEW ORLEANS TO ST. LOUIS 1210 MILES. Between the Steamers Robt. E. Lee Capt. JW Cannon and Natchez. Capt. T.P.Leathers. Won by The R.E. Lee. Time: 3 Days 18 Hours 30 Minutes.
This riverboat race was an event of some notoriety in its time, and numerous prints of the era were devoted to it. See also this print, which is of a different riverboat race.